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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Storer, R Ian; Pike, Andy; Swain, Nigel A; Alexandrou, Aristos J; Bechle, Bruce M; Blakemore, David C; Brown, Alan D; Castle, Neil A; Corbett, Matthew S; Flanagan, Neil J; Fengas, David; Johnson, M Scott; Jones, Lyn H; Marron, Brian E; Payne, C Elizabeth; Printzenhoff, David; Rawson, David J; Rose, Colin R; Ryckmans, Thomas; Sun, Jianmin; Theile, Jonathan W; Torella, Rubben; Tseng, Elaine; Warmus, Joseph S.
Afiliación
  • Storer RI; Worldwide Medicinal Chemistry, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK. Electronic address: ian.storer@astrazeneca.com.
  • Pike A; Pharmacokinetics, Dynamics and Metabolism, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Swain NA; Worldwide Medicinal Chemistry, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Alexandrou AJ; Electrophysiology, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Bechle BM; Worldwide Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Blakemore DC; Worldwide Medicinal Chemistry, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Brown AD; Worldwide Medicinal Chemistry, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Castle NA; Icagen Inc, 4222 Emperor Blvd #350, Durham, NC 27703, USA.
  • Corbett MS; Worldwide Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Flanagan NJ; Pharmaceutical Sciences, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Fengas D; Peakdale Molecular, Ltd, Discovery Park House, Ramsgate Road, Sandwich, Kent CT13 9ND, UK.
  • Johnson MS; Icagen Inc, 4222 Emperor Blvd #350, Durham, NC 27703, USA.
  • Jones LH; Worldwide Medicinal Chemistry, Pfizer Inc, 610 Main Street, Cambridge, MA 02139, USA.
  • Marron BE; Icagen Inc, 4222 Emperor Blvd #350, Durham, NC 27703, USA.
  • Payne CE; Electrophysiology, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Printzenhoff D; Icagen Inc, 4222 Emperor Blvd #350, Durham, NC 27703, USA.
  • Rawson DJ; Worldwide Medicinal Chemistry, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
  • Rose CR; Worldwide Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Ryckmans T; Worldwide Medicinal Chemistry, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
  • Sun J; Worldwide Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Theile JW; Icagen Inc, 4222 Emperor Blvd #350, Durham, NC 27703, USA.
  • Torella R; Worldwide Medicinal Chemistry, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, UK.
  • Tseng E; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, Eastern Point Road, Groton, CT 06340, USA.
  • Warmus JS; Worldwide Medicinal Chemistry, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
Bioorg Med Chem Lett ; 27(21): 4805-4811, 2017 11 01.
Article en En | MEDLINE | ID: mdl-29029933
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Sulfonamidas / Canal de Sodio Activado por Voltaje NAV1.7 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Sulfonamidas / Canal de Sodio Activado por Voltaje NAV1.7 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article