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Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.
George, Varghese; Harrison, Linda; Roach, Margaret; Li, Xiao-Dong; Tierney, Camlin; Fischl, Margaret A; Aberg, Judith; Tebas, Pablo; Asmuth, David M; Pollard, Richard B; Godfrey, Catherine; Pahwa, Savita.
Afiliación
  • George V; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Florida.
  • Harrison L; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public, Boston, Massachusetts.
  • Roach M; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Florida.
  • Li XD; Department of Internal Medicine, University of California, Davis School of Medicine, Sacramento.
  • Tierney C; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public, Boston, Massachusetts.
  • Fischl MA; AIDS Clinical Research Unit, Department of Medicine, University of Miami Miller School of Medicine, Florida.
  • Aberg J; Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Tebas P; Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
  • Asmuth DM; Department of Internal Medicine, University of California, Davis School of Medicine, Sacramento.
  • Pollard RB; Department of Internal Medicine, University of California, Davis School of Medicine, Sacramento.
  • Godfrey C; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Pahwa S; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Florida.
J Infect Dis ; 216(9): 1159-1163, 2017 11 27.
Article en En | MEDLINE | ID: mdl-29040604
ABSTRACT
A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/µL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/µL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Translocación Genética / Biomarcadores / Infecciones por VIH / Citocinas / Fármacos Anti-VIH / Síndrome Inflamatorio de Reconstitución Inmune Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Translocación Genética / Biomarcadores / Infecciones por VIH / Citocinas / Fármacos Anti-VIH / Síndrome Inflamatorio de Reconstitución Inmune Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article