Short- and long-term complications of in utero exposure to lamotrigine.
Br J Clin Pharmacol
; 84(1): 189-194, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-29044597
ABSTRACT
AIMS:
The present study evaluates the effect of antenatal lamotrigine exposure, on short- and long-term paediatric outcome.METHODS:
The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical centre between 2004-2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed a questionnaire regarding their child's development and health up to the age of 12 years.RESULTS:
No major malformations were found in the newborns. None of the newborns had significant withdrawal symptoms by Finnegan score. The children were followed-up to the age of 12 years (56.6% were 6-12 years at the time of evaluation). There were no significant findings in the incidence of neurodevelopmental disorders.CONCLUSIONS:
According to our experience, lamotrigine is generally safe for pregnancy use, associated with minimal short-term complications with no long-term effects on the outcome.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
/
Efectos Tardíos de la Exposición Prenatal
/
Triazinas
/
Epilepsia
/
Anticonvulsivantes
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Israel