Local translation of the Down syndrome cell adhesion molecule (DSCAM) mRNA in the vertebrate central nervous system.
J Neurogenet
; 31(4): 223-230, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-29078722
ABSTRACT
Local translation of synaptic mRNAs is an important process related to key aspects of central nervous system development and physiology, including dendritogenesis, axonal growth cone morphology and guidance and synaptic plasticity. Accordingly, local translation is compromised in several intellectual disabilities, including Fragile X syndrome, tuberous sclerosis and Down syndrome. Down Syndrome Cell Adhesion Molecule (DSCAM) is a gene with ascribed functions in neuronal wiring that belongs to the Down Syndrome Critical Region (DSCR) of chromosome 21. In this review, we discuss the evidence for local translation of the DSCAM mRNA in dendrites and axonal growth cones of mouse hippocampal neurons, as well as the possible functions of the locally translated DSCAM protein.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Moléculas de Adhesión Celular
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Síndrome de Down
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Dendritas
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Hipocampo
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Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurogenet
Año:
2017
Tipo del documento:
Article
País de afiliación:
España