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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
Cabrera, Alvaro Cortes; Melo, Esther; Roth, Doris; Topp, Andreas; Delobel, Frederic; Stucki, Corinne; Chen, Chia-Yi; Jakob, Peter; Banfai, Balazs; Dunkley, Tom; Schilling, Oliver; Huber, Sylwia; Iacone, Roberto; Petrone, Paula.
Afiliación
  • Cabrera AC; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Melo E; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Roth D; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Topp A; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Delobel F; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Stucki C; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Chen CY; Institute of Molecular Medicine and Cell Research, University of Freiburg, 79104, Freiburg, Germany.
  • Jakob P; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Banfai B; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Dunkley T; Soladis GmbH, 4052, Basel, Switzerland.
  • Schilling O; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
  • Huber S; Institute of Molecular Medicine and Cell Research, University of Freiburg, 79104, Freiburg, Germany.
  • Iacone R; BIOSS Centre for Biological Signaling Studies, University of Freiburg, D-79104, Freiburg, Germany.
  • Petrone P; Pharma Research & Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland.
Sci Rep ; 7(1): 14804, 2017 11 01.
Article en En | MEDLINE | ID: mdl-29093542

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Multimerización de Proteína / Proteolisis / Serina Peptidasa A1 que Requiere Temperaturas Altas Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Multimerización de Proteína / Proteolisis / Serina Peptidasa A1 que Requiere Temperaturas Altas Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Suiza