Prostaglandin E<sub>2</sub> Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells.

Heffner, Garrett C; Bonner, Melissa; Christiansen, Lauryn; Pierciey, Francis J; Campbell, Dakota; Smurnyy, Yegor; Zhang, Wenliang; Hamel, Amanda; Shaw, Seema; Lewis, Gretchen; Goss, Kendrick A; Garijo, Olivia; Torbett, Bruce E; Horton, Holly; Finer, Mitchell H; Gregory, Philip D; Veres, Gabor

Prostaglandin E₂ Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells.

Heffner, Garrett C; Bonner, Melissa; Christiansen, Lauryn; Pierciey, Francis J; Campbell, Dakota; Smurnyy, Yegor; Zhang, Wenliang; Hamel, Amanda; Shaw, Seema; Lewis, Gretchen; Goss, Kendrick A; Garijo, Olivia; Torbett, Bruce E; Horton, Holly; Finer, Mitchell H; Gregory, Philip D; Veres, Gabor.

Afiliación

Heffner GC; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA. Electronic address: gheffner@audentestx.com.
Bonner M; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Christiansen L; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Pierciey FJ; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Campbell D; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Smurnyy Y; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Zhang W; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Hamel A; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Shaw S; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Lewis G; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Goss KA; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Garijo O; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Torbett BE; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Horton H; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Finer MH; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Gregory PD; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.
Veres G; bluebird bio, Inc., 60 Binney Street, Cambridge, MA 02142, USA.

Mol Ther ; 26(1): 320-328, 2018 01 03.

Article en En | MEDLINE | ID: mdl-29102562

Asunto(s)

Dinoprostona/metabolismo; Vectores Genéticos/genética; Células Madre Hematopoyéticas/metabolismo; Lentivirus/genética; Transducción Genética; Anemia de Células Falciformes/genética; Anemia de Células Falciformes/metabolismo; Animales; Antígenos CD34/metabolismo; Línea Celular; Biblioteca de Genes; Técnicas de Transferencia de Gen; Terapia Genética; Globinas/genética; Humanos; Antígenos Comunes de Leucocito/metabolismo; Ratones; Transgenes; Trasplante Heterólogo; Internalización del Virus; Talasemia beta/genética; Talasemia beta/metabolismo

Palabras clave

gene therapy; hematopoietic stem cell; hemoglobinopathy; lentiviral vector; prostaglandin E(2); transduction; vector copy number

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción Genética / Células Madre Hematopoyéticas / Dinoprostona / Lentivirus / Vectores Genéticos Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article

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