Unconventional NMDA Receptor Signaling.
J Neurosci
; 37(45): 10800-10807, 2017 11 08.
Article
en En
| MEDLINE
| ID: mdl-29118208
ABSTRACT
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+ This review highlights novel findings concerning these unconventional modes of NMDAR action.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Receptores de N-Metil-D-Aspartato
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurosci
Año:
2017
Tipo del documento:
Article