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The Differential Effects of Human Immunodeficiency Virus and Hepatitis C Virus on Bone Microarchitecture and Fracture Risk.
Bedimo, Roger J; Adams-Huet, Beverley; Poindexter, John; Brown, Geri; Farukhi, Irfan; Castanon, Rosinda; Turner, Diana; Moore, Teresa; Tebas, Pablo; Maalouf, Naim M.
Afiliación
  • Bedimo RJ; Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center at Dallas.
  • Adams-Huet B; Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas.
  • Poindexter J; Center for Mineral Metabolism, University of Texas Southwestern Medical Center at Dallas.
  • Brown G; Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center at Dallas.
  • Farukhi I; Department of Nuclear Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center at Dallas.
  • Castanon R; Department of Nuclear Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center at Dallas.
  • Turner D; Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas.
  • Moore T; Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas.
  • Tebas P; Department of Medicine, University of Pennsylvania, Philadelphia.
  • Maalouf NM; Department of Medicine, University of Texas Southwestern Medical Center at Dallas.
Clin Infect Dis ; 66(9): 1442-1447, 2018 04 17.
Article en En | MEDLINE | ID: mdl-29145609
ABSTRACT

Background:

Human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected individuals have a significantly greater osteoporotic fracture risk than HIV-monoinfected persons, despite the fact that HIV/HCV coinfection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. To evaluate if changes in bone microarchitecture, measured by trabecular bone score (TBS), could explain these differences, we performed a prospective, cross-sectional cohort study of virologically suppressed HIV-infected subjects, untreated HCV-infected subjects, HIV/HCV-coinfected subjects, and uninfected controls.

Methods:

We enrolled 532 male

subjects:

57 HIV/HCV coinfected, 174 HIV infected, 123 HCV infected, and 178 controls. We conducted analysis of covariance comparing BMD and TBS between groups, controlling for age, race, body mass index, and smoking. We used linear regression to evaluate predictors of BMD and TBS and evaluated the effects of severity of HCV infection and tenofovir disoproxil fumarate use.

Results:

Despite both infections being associated with decreased BMD, only HCV, but not HIV, was associated with lower TBS score. Also, HIV/HCV-coinfected subjects had lower TBS scores than HIV-monoinfected, HCV-monoinfected, and uninfected subjects. Neither the use of TDF or HCV viremia nor the severity of HCV liver disease was associated with lower TBS.

Conclusions:

HCV infection is associated with microarchitectural changes at the lumbar spine as assessed by the low TBS score, suggesting that microstructural abnormalities underlie some of the higher fracture risk in HCV infection. TBS might improve fracture risk prediction in HCV infection.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Hepatitis C / Fracturas Óseas / Hueso Esponjoso Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Hepatitis C / Fracturas Óseas / Hueso Esponjoso Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article