Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I<sup>1/2</sup> Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation.

Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Liu, Qi; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I^1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation.

Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Liu, Qi; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun.

Afiliación

Pan P; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Yu H; Rongene Pharma Co., Ltd., Shenzhen, Guandong 518054, China.
Liu Q; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, China.
Kong X; Innovative Drug R & D Center, Shenzhen Salubris Pharmaceuticals Co., Ltd., Huabao Industrial Zone, Shenzhen 518102, China.
Chen H; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chen J; Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory of Translational Research and Therapy for Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.
Liu Q; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, China.
Li D; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, China.
Kang Y; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, China.
Sun H; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhou W; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Tian S; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Cui S; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhu F; Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory of Translational Research and Therapy for Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.
Li Y; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Huang Y; College of Pharmaceutical Sciences and State Key Lab of CAD&CG, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Hou T; Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory of Translational Research and Therapy for Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.

ACS Cent Sci ; 3(11): 1208-1220, 2017 Nov 22.

Article en En | MEDLINE | ID: mdl-29202023

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ACS Cent Sci Año: 2017 Tipo del documento: Article País de afiliación: China

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