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The diphenylpyrazole compound anle138b blocks Aß channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Martinez Hernandez, Ana; Urbanke, Hendrik; Gillman, Alan L; Lee, Joon; Ryazanov, Sergey; Agbemenyah, Hope Y; Benito, Eva; Jain, Gaurav; Kaurani, Lalit; Grigorian, Gayane; Leonov, Andrei; Rezaei-Ghaleh, Nasrollah; Wilken, Petra; Arce, Fernando Teran; Wagner, Jens; Fuhrmann, Martin; Caruana, Mario; Camilleri, Angelique; Vassallo, Neville; Zweckstetter, Markus; Benz, Roland; Giese, Armin; Schneider, Anja; Korte, Martin; Lal, Ratnesh; Griesinger, Christian; Eichele, Gregor; Fischer, Andre.
Afiliación
  • Martinez Hernandez A; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
  • Urbanke H; Department for Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Gillman AL; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
  • Lee J; Department of Bioengineering, Materials Science and Engineering, Department of Mechanical and Aerospace Engineering and Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
  • Ryazanov S; Department of Bioengineering, Materials Science and Engineering, Department of Mechanical and Aerospace Engineering and Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
  • Agbemenyah HY; Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Benito E; DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.
  • Jain G; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
  • Kaurani L; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
  • Grigorian G; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
  • Leonov A; DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.
  • Rezaei-Ghaleh N; Department of Cellular Neurobiology, Technical University Braunschweig, Braunschweig, Germany.
  • Wilken P; Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Arce FT; DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.
  • Wagner J; Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Fuhrmann M; Department of Translational Structural Biology of Dementia, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
  • Caruana M; DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.
  • Camilleri A; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
  • Vassallo N; Group for Translational Research in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
  • Zweckstetter M; Department of Bioengineering, Materials Science and Engineering, Department of Mechanical and Aerospace Engineering and Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
  • Benz R; Group for Neuroimmunology and Imaging, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Giese A; Group for Neuroimmunology and Imaging, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Schneider A; Department of Physiology and Biochemistry, Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.
  • Korte M; Department of Physiology and Biochemistry, Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.
  • Lal R; Department of Physiology and Biochemistry, Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.
  • Griesinger C; Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Eichele G; DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.
  • Fischer A; Department of Translational Structural Biology of Dementia, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
EMBO Mol Med ; 10(1): 32-47, 2018 01.
Article en En | MEDLINE | ID: mdl-29208638
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Péptidos beta-Amiloides / Benzodioxoles / Enfermedad de Alzheimer / Hipocampo Límite: Animals Idioma: En Revista: EMBO Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Péptidos beta-Amiloides / Benzodioxoles / Enfermedad de Alzheimer / Hipocampo Límite: Animals Idioma: En Revista: EMBO Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Alemania