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Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
Lagares, David; Santos, Alba; Grasberger, Paula E; Liu, Fei; Probst, Clemens K; Rahimi, Rod A; Sakai, Norihiko; Kuehl, Tobias; Ryan, Jeremy; Bhola, Patrick; Montero, Joan; Kapoor, Mohit; Baron, Murray; Varelas, Xaralabos; Tschumperlin, Daniel J; Letai, Anthony; Tager, Andrew M.
Afiliación
  • Lagares D; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. dlagares@mgh.harvard.edu.
  • Santos A; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Grasberger PE; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Liu F; Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Probst CK; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Rahimi RA; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Sakai N; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Kuehl T; Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
  • Ryan J; Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Bhola P; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Montero J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Kapoor M; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Baron M; Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Varelas X; Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
  • Tschumperlin DJ; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Letai A; Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Tager AM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Sci Transl Med ; 9(420)2017 Dec 13.
Article en En | MEDLINE | ID: mdl-29237758
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Apoptosis / Miofibroblastos / Compuestos de Anilina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Apoptosis / Miofibroblastos / Compuestos de Anilina Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos