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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Koltun, Dmitry O; Parkhill, Eric Q; Kalla, Rao; Perry, Thao D; Elzein, Elfatih; Li, Xiaofen; Simonovich, Scott P; Ziebenhaus, Christopher; Hansen, Timothy R; Marchand, Bruno; Hung, WaiLok K; Lagpacan, Leanna; Hung, Magdeleine; Aoyama, Ron G; Murray, Bernard P; Perry, Jason K; Somoza, John R; Villaseñor, Armando G; Pagratis, Nikos; Zablocki, Jeff A.
Afiliación
  • Koltun DO; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States. Electronic address: dmitry.koltun@gilead.com.
  • Parkhill EQ; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Kalla R; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Perry TD; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Elzein E; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Li X; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Simonovich SP; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Ziebenhaus C; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Hansen TR; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Marchand B; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Hung WK; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Lagpacan L; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Hung M; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Aoyama RG; Department of Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Murray BP; Department of Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Perry JK; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Somoza JR; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Villaseñor AG; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Pagratis N; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
  • Zablocki JA; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.
Bioorg Med Chem Lett ; 28(3): 541-546, 2018 02 01.
Article en En | MEDLINE | ID: mdl-29254643
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteínas Quinasas / Proteína Quinasa Tipo 2 Dependiente de Calcio Calmodulina / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteínas Quinasas / Proteína Quinasa Tipo 2 Dependiente de Calcio Calmodulina / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article