First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.

Helle, Emmi I T; Biegley, Preston; Knowles, Joshua W; Leader, Joseph B; Pendergrass, Sarah; Yang, Wei; Reaven, Gerald R; Shaw, Gary M; Ritchie, Marylyn; Priest, James R

Helle, Emmi I T; Biegley, Preston; Knowles, Joshua W; Leader, Joseph B; Pendergrass, Sarah; Yang, Wei; Reaven, Gerald R; Shaw, Gary M; Ritchie, Marylyn; Priest, James R.

Afiliación

Helle EIT; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Children's Hospital, University of Helsinki, Helsinki, Finland.
Biegley P; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
Knowles JW; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA.
Leader JB; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
Pendergrass S; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
Yang W; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Reaven GR; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA.
Shaw GM; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Ritchie M; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA.
Priest JR; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA. Electronic address: jpriest@stanford.edu.

J Pediatr ; 195: 275-278, 2018 04.

Article en En | MEDLINE | ID: mdl-29254757

RESUMEN

In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.

Asunto(s)

Glucemia/metabolismo; Cardiopatías Congénitas/etiología; Hiperglucemia/diagnóstico; Complicaciones del Embarazo/diagnóstico; Primer Trimestre del Embarazo/sangre; Adolescente; Adulto; Biomarcadores/sangre; Femenino; Humanos; Hiperglucemia/sangre; Recién Nacido; Embarazo; Complicaciones del Embarazo/sangre; Estudios Retrospectivos; Factores de Riesgo; Adulto Joven

Palabras clave

congenital heart disease; congenital malformation; diabetes; oral glucose tolerance test; plasma glucose

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Primer Trimestre del Embarazo / Glucemia / Cardiopatías Congénitas / Hiperglucemia Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Pediatr Año: 2018 Tipo del documento: Article País de afiliación: Finlandia

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