Associated factors of umbilical cord blood collection quality.
Transfusion
; 58(2): 520-531, 2018 02.
Article
en En
| MEDLINE
| ID: mdl-29277910
ABSTRACT
After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conservación de la Sangre
/
Trasplante de Células Madre de Sangre del Cordón Umbilical
/
Sangre Fetal
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Transfusion
Año:
2018
Tipo del documento:
Article