Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-&#954;B activity and increases drug resistance in multiple myeloma.

Huynh, Mailee; Pak, Chorom; Markovina, Stephanie; Callander, Natalie S; Chng, Kenneth S; Wuerzberger-Davis, Shelly M; Bakshi, Debayan D; Kink, John A; Hematti, Peiman; Hope, Chelsea; Asimakopoulos, Fotis; Rui, Lixin; Miyamoto, Shigeki

Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma.

Huynh, Mailee; Pak, Chorom; Markovina, Stephanie; Callander, Natalie S; Chng, Kenneth S; Wuerzberger-Davis, Shelly M; Bakshi, Debayan D; Kink, John A; Hematti, Peiman; Hope, Chelsea; Asimakopoulos, Fotis; Rui, Lixin; Miyamoto, Shigeki.

Afiliación

Huynh M; From the Cancer Biology Graduate Program.
Pak C; the Molecular and Cellular Pharmacology Graduate Program.
Markovina S; the Cellular and Molecular Biology Graduate Program.
Callander NS; the Medical Sciences Training Program.
Chng KS; the University of Wisconsin Carbone Cancer Center.
Wuerzberger-Davis SM; the Department of Medicine.
Bakshi DD; the McArdle Laboratory of Cancer Research, and.
Kink JA; the Department of Oncology, University of Wisconsin, Madison, Wisconsin 53705.
Hematti P; the McArdle Laboratory of Cancer Research, and.
Hope C; the Department of Oncology, University of Wisconsin, Madison, Wisconsin 53705.
Asimakopoulos F; the Cellular and Molecular Biology Graduate Program.
Rui L; the University of Wisconsin Carbone Cancer Center.
Miyamoto S; the University of Wisconsin Carbone Cancer Center.

J Biol Chem ; 293(7): 2452-2465, 2018 02 16.

Article en En | MEDLINE | ID: mdl-29279332

Asunto(s)

Antineoplásicos/farmacología; Bortezomib/farmacología; Proteínas de la Matriz Extracelular/metabolismo; Mieloma Múltiple/metabolismo; FN-kappa B/metabolismo; Proteoglicanos/metabolismo; Células de la Médula Ósea/efectos de los fármacos; Células de la Médula Ósea/metabolismo; Resistencia a Antineoplásicos; Proteínas de la Matriz Extracelular/genética; Humanos; Proteínas I-kappa B/genética; Proteínas I-kappa B/metabolismo; Mieloma Múltiple/tratamiento farmacológico; Mieloma Múltiple/genética; FN-kappa B/genética; Complejo de la Endopetidasa Proteasomal/genética; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteoglicanos/genética; Proteolisis

Palabras clave

NF-kappa B (NF-KB); bortezomib; drug resistance; extracellular matrix protein; hyaluronan and proteoglycan link protein 1 (HAPLN1); matrikine; molecular biology; multiple myeloma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteoglicanos / Proteínas de la Matriz Extracelular / FN-kappa B / Bortezomib / Mieloma Múltiple / Antineoplásicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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