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Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.
Nielsen, Jonas B; Fritsche, Lars G; Zhou, Wei; Teslovich, Tanya M; Holmen, Oddgeir L; Gustafsson, Stefan; Gabrielsen, Maiken E; Schmidt, Ellen M; Beaumont, Robin; Wolford, Brooke N; Lin, Maoxuan; Brummett, Chad M; Preuss, Michael H; Refsgaard, Lena; Bottinger, Erwin P; Graham, Sarah E; Surakka, Ida; Chu, Yunhan; Skogholt, Anne Heidi; Dalen, Håvard; Boyle, Alan P; Oral, Hakan; Herron, Todd J; Kitzman, Jacob; Jalife, José; Svendsen, Jesper H; Olesen, Morten S; Njølstad, Inger; Løchen, Maja-Lisa; Baras, Aris; Gottesman, Omri; Marcketta, Anthony; O'Dushlaine, Colm; Ritchie, Marylyn D; Wilsgaard, Tom; Loos, Ruth J F; Frayling, Timothy M; Boehnke, Michael; Ingelsson, Erik; Carey, David J; Dewey, Frederick E; Kang, Hyun M; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J.
Afiliación
  • Nielsen JB; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Fritsche LG; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health,
  • Zhou W; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Teslovich TM; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • Holmen OL; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department
  • Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden.
  • Gabrielsen ME; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Schmidt EM; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Beaumont R; Royal Devon & Exeter NHS Foundation Trust and University of Exeter Barrack Road Exeter, Exeter EX2 5WD, UK.
  • Wolford BN; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lin M; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Brummett CM; Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Refsgaard L; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
  • Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Graham SE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  • Surakka I; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  • Chu Y; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Skogholt AH; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Dalen H; Department of Cardiology, St. Olav's University Hospital, Trondheim 7030, Norway; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger 7600, Norway; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Boyle AP; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Oral H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  • Herron TJ; Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA.
  • Kitzman J; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Jalife J; Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA; Fundacion Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain.
  • Svendsen JH; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
  • Olesen MS; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; Department of Biomedicine, University of Copenhagen, Copenhagen 2200, Denmark.
  • Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø 9019, Norway.
  • Løchen ML; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø 9019, Norway.
  • Baras A; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • Gottesman O; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • Marcketta A; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • O'Dushlaine C; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • Ritchie MD; Geisinger Health System, Danville, PA 17822, USA.
  • Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø 9019, Norway.
  • Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Frayling TM; Royal Devon & Exeter NHS Foundation Trust and University of Exeter Barrack Road Exeter, Exeter EX2 5WD, UK.
  • Boehnke M; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Carey DJ; Geisinger Health System, Danville, PA 17822, USA.
  • Dewey FE; Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  • Kang HM; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Abecasis GR; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway.
  • Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department
  • Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Cente
Am J Hum Genet ; 102(1): 103-115, 2018 01 04.
Article en En | MEDLINE | ID: mdl-29290336
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrilación Atrial / Secuencias Reguladoras de Ácidos Nucleicos / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Sitios Genéticos / Corazón Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrilación Atrial / Secuencias Reguladoras de Ácidos Nucleicos / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Sitios Genéticos / Corazón Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos