Parasitological and immunological evaluation of cattle experimentally infected with Trypanosoma vivax.
Exp Parasitol
; 185: 98-106, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29309784
ABSTRACT
Trypanosoma vivax infection causes relevant economical impact due to high morbidity and mortality leading to negative impact on local livestock. Despite parasitological and serological methods are used for the diagnosis of T. vivax infection, gaps regarding sensitivity and specificity of these methods still represent a challenge. The present study aimed to compare the kinetics of parasitological and serological parameters in cattle experimentally infected with T. vivax along with immunophenotypic analysis of whole blood leukocytes. Based on the parasitemia profile the analysis were performed in three distinct periods, referred as pre-patent, patent and post-treatment. Distinct kinetics of anti-T. vivax IgM and IgG were observed during the pre-patent, patent and post-treatment periods. Increased levels of WC1+ γδ T-cells were observed throughout the infection with strong correlations with other biomarkers observed during post-treatment period. Our findings demonstrated that there is a important participation of MonocytesCD14+; NK-cellsCD335+ and WC1+ γδ T-cells that coincide with the peak of parasitemia and also with the adaptive immunity, specially CD4+ T-cells in T. vivax infection. The knowledge of the immune response is important not only for understanding the biology of the parasite in the host, but for the design of new treatment strategies for trypanosome infections.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tripanosomiasis Africana
/
Enfermedades de los Bovinos
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Trypanosoma vivax
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Parasitemia
Límite:
Animals
Idioma:
En
Revista:
Exp Parasitol
Año:
2018
Tipo del documento:
Article