Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.

McGreal, Steven R; Bhushan, Bharat; Walesky, Chad; McGill, Mitchell R; Lebofsky, Margitta; Kandel, Sylvie E; Winefield, Robert D; Jaeschke, Hartmut; Zachara, Natasha E; Zhang, Zhen; Tan, Ee Phie; Slawson, Chad; Apte, Udayan

McGreal, Steven R; Bhushan, Bharat; Walesky, Chad; McGill, Mitchell R; Lebofsky, Margitta; Kandel, Sylvie E; Winefield, Robert D; Jaeschke, Hartmut; Zachara, Natasha E; Zhang, Zhen; Tan, Ee Phie; Slawson, Chad; Apte, Udayan.

Afiliación

McGreal SR; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Bhushan B; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Walesky C; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
McGill MR; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Lebofsky M; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Kandel SE; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Winefield RD; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Jaeschke H; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Zachara NE; Department of Biological Chemistry, The John Hopkins School of Medicine, Baltimore, Maryland 21205.
Zhang Z; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas 66160.
Tan EP; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas 66160.
Slawson C; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas 66160.
Apte U; The Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.

Toxicol Sci ; 162(2): 599-610, 2018 04 01.

Article en En | MEDLINE | ID: mdl-29325178

Asunto(s)

Acetaminofén/toxicidad; Acetilglucosamina/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Glutatión/biosíntesis; Hígado/efectos de los fármacos; N-Acetilglucosaminiltransferasas/metabolismo; Acetaminofén/metabolismo; Acilación; Animales; Enfermedad Hepática Inducida por Sustancias y Drogas/etiología; Enfermedad Hepática Inducida por Sustancias y Drogas/patología; Glutatión/genética; Hígado/metabolismo; Hígado/patología; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; N-Acetilglucosaminiltransferasas/genética; Unión Proteica

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilglucosamina / N-Acetilglucosaminiltransferasas / Enfermedad Hepática Inducida por Sustancias y Drogas / Glutatión / Hígado / Acetaminofén Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google