Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging.

Henry, Lucas; Delsuc, Nicolas; Laugel, Cécile; Lambert, François; Sandt, Christophe; Hostachy, Sarah; Bernard, Anne-Sophie; Bertrand, Hélène C; Grimaud, Laurence; Baillet-Guffroy, Arlette; Policar, Clotilde

Henry, Lucas; Delsuc, Nicolas; Laugel, Cécile; Lambert, François; Sandt, Christophe; Hostachy, Sarah; Bernard, Anne-Sophie; Bertrand, Hélène C; Grimaud, Laurence; Baillet-Guffroy, Arlette; Policar, Clotilde.

Afiliación

Henry L; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Delsuc N; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Laugel C; Laboratory of Analytical Chemistry, Lip(Sys)2, (EA 7357), Faculty of Pharmacy, Paris-Sud , University of Paris-Saclay , 5 Rue Jean-Baptiste Clément , 92296 Chatenay-Malabry , France.
Lambert F; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Sandt C; SMIS beamline , Synchrotron SOLEIL Saint-Aubin , 91192 Gif-sur-Yvette Cedex , France.
Hostachy S; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Bernard AS; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Bertrand HC; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Grimaud L; PASTEUR, Département de chimie, École normale supérieure, PSL Research University, Sorbonne Universités, UPMC Univ. Paris 06, CNRS , 75005 Paris , France.
Baillet-Guffroy A; Laboratory of Analytical Chemistry, Lip(Sys)2, (EA 7357), Faculty of Pharmacy, Paris-Sud , University of Paris-Saclay , 5 Rue Jean-Baptiste Clément , 92296 Chatenay-Malabry , France.
Policar C; Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.

Bioconjug Chem ; 29(4): 987-991, 2018 04 18.

Article en En | MEDLINE | ID: mdl-29360339

ABSTRACT

ABSTRACT

Hyaluronic acids were labeled with a rhenium-tricarbonyl used as single core multimodal probe for imaging and their penetration into human skin biopsies was studied using IR microscopy and fluorescence imaging (labeled SCoMPI). The penetration was shown to be dependent on the molecular weight of the molecule and limited to the upper layer of the skin.

Asunto(s)

Colorantes Fluorescentes/química; Ácido Hialurónico/farmacocinética; Imagen Óptica/métodos; Renio/química; Piel/metabolismo; Humanos; Ácido Hialurónico/análisis; Rayos Infrarrojos; Microscopía/métodos; Microscopía Fluorescente/métodos; Imagen Multimodal/métodos; Absorción Cutánea; Espectroscopía Infrarroja por Transformada de Fourier/métodos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Renio / Piel / Imagen Óptica / Colorantes Fluorescentes / Ácido Hialurónico Límite: Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Francia

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