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Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors.
Deng, Xinxian; Shen, Jian; Zhu, Hui; Xiao, Jia; Sun, Ran; Xie, Fangzhou; Lam, Celine; Wang, Juntao; Qiao, Yixue; Tavallaie, Mojdeh S; Hu, Yang; Du, Yi; Li, Jianqi; Fu, Lei; Jiang, Faqin.
Afiliación
  • Deng X; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China; China State Institute of Pharmaceutical Industry, No. 285 Gebaini Rd., Pudong District, Shanghai 201203, China.
  • Shen J; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China; Viva Biotech Ltd. (Shanghai), No. 334 Aidisheng Rd., Pudong District, Shanghai 201203, China.
  • Zhu H; Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 369 Zhizaoju Road, Huangpu District, Shanghai 200011, China.
  • Xiao J; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Sun R; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Xie F; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Lam C; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Wang J; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Qiao Y; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Tavallaie MS; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Hu Y; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China.
  • Du Y; Xinhua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Rd., Yangpu District, Shanghai 200092, China.
  • Li J; China State Institute of Pharmaceutical Industry, No. 285 Gebaini Rd., Pudong District, Shanghai 201203, China. Electronic address: lijianqb@126.com.
  • Fu L; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China. Electronic address: leifu@sjtu.edu.cn.
  • Jiang F; School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai 200240, China. Electronic address: jfq2008@sjtu.edu.cn.
Bioorg Med Chem ; 26(4): 903-912, 2018 02 15.
Article en En | MEDLINE | ID: mdl-29373269
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinonas / Dipeptidil Peptidasa 4 / Inhibidores de la Dipeptidil-Peptidasa IV / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinonas / Dipeptidil Peptidasa 4 / Inhibidores de la Dipeptidil-Peptidasa IV / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China