Reconstructing the genetic history of Italians: new insights from a male (Y-chromosome) perspective.
Ann Hum Biol
; 45(1): 44-56, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29382284
ABSTRACT
BACKGROUND:
Due to its central and strategic position in Europe and in the Mediterranean Basin, the Italian Peninsula played a pivotal role in the first peopling of the European continent and has been a crossroad of peoples and cultures since then.AIM:
This study aims to gain more information on the genetic structure of modern Italian populations and to shed light on the migration/expansion events that led to their formation. SUBJECTS ANDMETHODS:
High resolution Y-chromosome variation analysis in 817 unrelated males from 10 informative areas of Italy was performed. Haplogroup frequencies and microsatellite haplotypes were used, together with available data from the literature, to evaluate Mediterranean and European inputs and date their arrivals.RESULTS:
Fifty-three distinct Y-chromosome lineages were identified. Their distribution is in general agreement with geography, southern populations being more differentiated than northern ones.CONCLUSIONS:
A complex genetic structure reflecting the multifaceted peopling pattern of the Peninsula emerged southern populations show high similarity with those from the Middle East and Southern Balkans, while those from Northern Italy are close to populations of North-Western Europe and the Northern Balkans. Interestingly, the population of Volterra, an ancient town of Etruscan origin in Tuscany, displays a unique Y-chromosomal genetic structure.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Haplotipos
/
ADN Mitocondrial
/
Repeticiones de Microsatélite
/
Cromosomas Humanos Y
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Hum Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia