Genome and epigenome engineering CRISPR toolkit for <i>in vivo</i> modulation of <i>cis</i>-regulatory interactions and gene expression in the chicken embryo.

Williams, Ruth M; Senanayake, Upeka; Artibani, Mara; Taylor, Gunes; Wells, Daniel; Ahmed, Ahmed Ashour; Sauka-Spengler, Tatjana

Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo.

Williams, Ruth M; Senanayake, Upeka; Artibani, Mara; Taylor, Gunes; Wells, Daniel; Ahmed, Ahmed Ashour; Sauka-Spengler, Tatjana.

Afiliación

Williams RM; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.
Senanayake U; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.
Artibani M; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.
Taylor G; University of Oxford, Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, UK.
Wells D; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.
Ahmed AA; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.
Sauka-Spengler T; University of Oxford, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.

Development ; 145(4)2018 02 23.

Article en En | MEDLINE | ID: mdl-29386245

Asunto(s)

Sistemas CRISPR-Cas/genética; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas/genética; Epigenómica/métodos; Ingeniería Genética/métodos; Animales; Embrión de Pollo; Pollos/genética; Clonación de Organismos; Electroporación; Técnica del Anticuerpo Fluorescente; Expresión Génica; Hibridación in Situ; Reacción en Cadena de la Polimerasa

Palabras clave

CRISPR; Chicken; Enhancer; Neural crest; dCas9-KRAB; dCas9-LSD1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ingeniería Genética / Epigenómica / Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas / Sistemas CRISPR-Cas Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido

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