SLFN11 Blocks Stressed Replication Forks Independently of ATR.

Murai, Junko; Tang, Sai-Wen; Leo, Elisabetta; Baechler, Simone A; Redon, Christophe E; Zhang, Hongliang; Al Abo, Muthana; Rajapakse, Vinodh N; Nakamura, Eijiro; Jenkins, Lisa M Miller; Aladjem, Mirit I; Pommier, Yves

Murai, Junko; Tang, Sai-Wen; Leo, Elisabetta; Baechler, Simone A; Redon, Christophe E; Zhang, Hongliang; Al Abo, Muthana; Rajapakse, Vinodh N; Nakamura, Eijiro; Jenkins, Lisa M Miller; Aladjem, Mirit I; Pommier, Yves.

Afiliación

Murai J; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: junko.murai@nih.gov.
Tang SW; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Leo E; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Baechler SA; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Redon CE; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Zhang H; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Al Abo M; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Rajapakse VN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nakamura E; DSK project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto 606-8397, Japan.
Jenkins LMM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Aladjem MI; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: pommier@nih.gov.

Mol Cell ; 69(3): 371-384.e6, 2018 02 01.

Article en En | MEDLINE | ID: mdl-29395061

Asunto(s)

Proteínas Nucleares/genética; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Camptotecina; Proteínas de Ciclo Celular/metabolismo; Línea Celular Tumoral; Cromatina/metabolismo; Daño del ADN; ADN Helicasas/metabolismo; Replicación del ADN/genética; Replicación del ADN/fisiología; ADN de Cadena Simple/genética; ADN de Cadena Simple/metabolismo; Humanos; Proteínas de Mantenimiento de Minicromosoma/metabolismo; Proteínas Nucleares/metabolismo; Pirazinas; Pirazoles; Proteína de Replicación A/metabolismo

Palabras clave

ATAC-seq; ATR; CHK1; PARP inhibitors; SLFN11; camptothecin; cell cycle checkpoints; hydroxyurea; prexasertib (LY2606368); replication origin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Nucleares Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article

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