Separation and quantitation of eight isomers in a molecule with three stereogenic centers by normal phase liquid chromatography.

Joshi, Nilesh; Dhamarlapati, Balaji; Pillai, Athimoolam; Paulose, Justine; Tan, Jessica; Blue, Laura E; Tedrow, Jason; Farrell, Bob

Joshi, Nilesh; Dhamarlapati, Balaji; Pillai, Athimoolam; Paulose, Justine; Tan, Jessica; Blue, Laura E; Tedrow, Jason; Farrell, Bob.

Afiliación

Joshi N; Syngene Amgen Research and Development Centre (SARC), Syngene International Ltd, Biocon Park, Bangalore,560099, India. Electronic address: nilesh.joshi@syngeneintl.com.
Dhamarlapati B; Syngene Amgen Research and Development Centre (SARC), Syngene International Ltd, Biocon Park, Bangalore,560099, India.
Pillai A; Syngene Amgen Research and Development Centre (SARC), Syngene International Ltd, Biocon Park, Bangalore,560099, India.
Paulose J; Syngene Amgen Research and Development Centre (SARC), Syngene International Ltd, Biocon Park, Bangalore,560099, India.
Tan J; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
Blue LE; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
Tedrow J; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
Farrell B; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.

J Chromatogr A ; 1538: 108-111, 2018 Feb 23.

Article en En | MEDLINE | ID: mdl-29397985

Asunto(s)

Química Farmacéutica/métodos; Cromatografía Liquida; Celulosa/análogos & derivados; Celulosa/química; Isomerismo; Límite de Detección; Cloruro de Metileno/química; Fenilcarbamatos/química; Estereoisomerismo; Temperatura

Palabras clave

Chiral separation; Chiralcel OD-H; Dichloromethane; HPLC; Normal phase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Química Farmacéutica / Cromatografía Liquida Idioma: En Revista: J Chromatogr A Año: 2018 Tipo del documento: Article

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