The antimicrobial cathelicidin peptide hlF(1-11) attenuates alveolar macrophage pyroptosis induced by Acinetobacter baumannii in vivo.
Exp Cell Res
; 364(1): 95-103, 2018 03 01.
Article
en En
| MEDLINE
| ID: mdl-29409862
ABSTRACT
Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections, including bacterial pneumonia. The hLF(1-11) peptide comprising the first 11 N-terminal residues of human lactoferrin exerts antimicrobial activity in vivo and was highly effective against multidrug-resistant A. baumannii strains in vitro and in vivo. Pyroptosis is a caspase-1-dependent inflammatory cell death process and is induced by various microbial infections. In the present study, we investigated the molecular mechanisms that regulate pyroptosis induced by A. baumannii in macrophages. Our results revealed that A. baumannii induced pyroptosis through caspase-1 activation and IL-1ß production. We also found that caspase-1 activation and IL-1ß maturation in A. baumannii-triggered pyroptotic cell death were reduced by hLF(1-11) treatment. Moreover, hLF(1-11) inhibited the A. baumannii-induced caspase-1 activation and pyroptosis of pulmonary alveolar macrophages in vivo.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Infecciones por Acinetobacter
/
Macrófagos Alveolares
/
Péptidos Catiónicos Antimicrobianos
/
Acinetobacter baumannii
/
Piroptosis
/
Lactoferrina
/
Antibacterianos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Exp Cell Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
China