Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants.
J Infect Dis
; 217(10): 1553-1560, 2018 04 23.
Article
en En
| MEDLINE
| ID: mdl-29415208
ABSTRACT
Current evidence suggests that malarial infection could alter metabolites in the breath of patients, a phenomenon that could be exploited to create a breath-based diagnostic test. However, no study has explored this in a clinical setting. To investigate whether natural human malarial infection leads to a characteristic breath profile, we performed a field study in Malawi. Breath volatiles from children with and those without uncomplicated falciparum malaria were analyzed by thermal desorption-gas chromatography/mass spectrometry. Using an unbiased, correlation-based analysis, we found that children with malaria have a distinct shift in overall breath composition. Highly accurate classification of infection status was achieved with a suite of 6 compounds. In addition, we found that infection correlates with significantly higher breath levels of 2 mosquito-attractant terpenes, α-pinene and 3-carene. These findings attest to the viability of breath analysis for malaria diagnosis, identify candidate biomarkers, and identify plausible chemical mediators for increased mosquito attraction to patients infected with malaria parasites.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Malaria Falciparum
/
Compuestos Orgánicos Volátiles
/
Anopheles
/
Odorantes
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Child
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Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Año:
2018
Tipo del documento:
Article