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A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.
Xing, Yanjiang; Zhao, Shuang; Wei, Qingxia; Gong, Shiqiang; Zhao, Xin; Zhou, Fang; Ai-Lamki, Rafia; Ortmann, Daniel; Du, Mingxia; Pedersen, Roger; Shang, Guangdong; Si, Shuyi; Morrell, Nicholas W; Yang, Jun.
Afiliación
  • Xing Y; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Zhao S; These authors contributed equally.
  • Wei Q; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Gong S; These authors contributed equally.
  • Zhao X; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Zhou F; These authors contributed equally.
  • Ai-Lamki R; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Ortmann D; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Du M; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Pedersen R; Dept of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
  • Shang G; The Anne McLaren Laboratory for Regenerative Medicine, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Si S; State Key Laboratory of Medical Molecular Biology, Dept of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
  • Morrell NW; The Anne McLaren Laboratory for Regenerative Medicine, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Yang J; Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Eur Respir J ; 51(4)2018 04.
Article en En | MEDLINE | ID: mdl-29449428
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Células Endoteliales / Ciclooxigenasa 2 / Proteína Morfogenética Ósea 2 / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Eur Respir J Año: 2018 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Células Endoteliales / Ciclooxigenasa 2 / Proteína Morfogenética Ósea 2 / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Eur Respir J Año: 2018 Tipo del documento: Article País de afiliación: China