Inflammation NODs to Antagonists of RIP2-XIAP Interaction.

Xia, Shiyu; Fu, Tian-Min; Wu, Hao

Xia, Shiyu; Fu, Tian-Min; Wu, Hao.

Afiliación

Xia S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: wu@crystal.harvard.edu.

Mol Cell ; 69(4): 535-536, 2018 02 15.

Article en En | MEDLINE | ID: mdl-29452633

ABSTRACT

ABSTRACT

While innate immunity is crucial for host defense, dysregulated signaling activation leads to pathological inflammation. In this issue of Molecular Cell, Goncharov et al. (2018) present a strategy to combat inflammatory diseases by disrupting RIP2-XIAP interaction in NOD2-mediated signaling.

Asunto(s)

Proteína Adaptadora de Señalización NOD2; Proteína Serina-Treonina Quinasa 2 de Interacción con Receptor; Humanos; Inmunidad Innata; Inflamación; Transducción de Señal; Proteína Inhibidora de la Apoptosis Ligada a X

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína Serina-Treonina Quinasa 2 de Interacción con Receptor / Proteína Adaptadora de Señalización NOD2 Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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