Chaperone substrate provides missing link for cancer drug discovery.
J Biol Chem
; 293(7): 2381-2382, 2018 02 16.
Article
en En
| MEDLINE
| ID: mdl-29453286
ABSTRACT
Both Hsp70 and Hsp90 chaperones are overexpressed in cancer, making them relevant targets for the development of cancer chemotherapeutics, but a lack of biomolecular readouts for Hsp70 inhibition has limited the pursuit of specific inhibitors for this enzyme. A new study from Cesa et al. identifies two inhibitors of apoptosis proteins (IAPs) as specific client substrates of Hsp70. These results establish biomarkers that can be utilized to monitor Hsp70 inhibition and provide a framework for future efforts to deconvolute chaperone networks.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas HSP90 de Choque Térmico
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Proteínas HSP70 de Choque Térmico
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Descubrimiento de Drogas
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Biol Chem
Año:
2018
Tipo del documento:
Article