Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.
Horm Behav
; 104: 130-137, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29505763
ABSTRACT
Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and ß (ERα and ERß) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Estrógenos
/
Receptores de Glutamato Metabotrópico
/
Trastornos Relacionados con Sustancias
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Horm Behav
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos