Number needed to treat in indirect treatment comparison.
J Comp Eff Res
; 7(3): 259-269, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29537878
ABSTRACT
AIM:
For dichotomous outcomes, odds ratio (OR) is one of the usual summary measures of indirect treatment comparison. A corresponding number needed to treat (NNT) estimate may facilitate understanding of the treatment effect.METHODS:
We show how to estimate NNT based on OR results of a matching adjusted indirect comparison. We also have derived the explicit formula of its 95% CIs by applying the delta method, and as an alternative, a simulation-based method.RESULTS:
The method was applied in a case study example in radioiodine-refractory differentiated thyroid cancer (RR-DTC) patients, comparing lenvatinib to sorafenib. For every two RR-DTC patients treated with lenvatinib instead of sorafenib, one fewer would have progressed and for every eight RR-DTC patients treated with lenvatinib instead of sorafenib, one fewer would have died.CONCLUSION:
Using NNT to summarize the results of a matching adjusted indirect comparison can help the clinicians to better understand the results in addition to OR.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Números Necesarios a Tratar
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Comp Eff Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia