Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics.
Thorax
; 73(12): 1170-1173, 2018 12.
Article
en En
| MEDLINE
| ID: mdl-29563159
ABSTRACT
In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipersensibilidad Respiratoria
/
Asma
/
Alternaria
/
Antígenos Fúngicos
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Thorax
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos