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Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Pereira, Ethel R; Kedrin, Dmitriy; Seano, Giorgio; Gautier, Olivia; Meijer, Eelco F J; Jones, Dennis; Chin, Shan-Min; Kitahara, Shuji; Bouta, Echoe M; Chang, Jonathan; Beech, Elizabeth; Jeong, Han-Sin; Carroll, Michael C; Taghian, Alphonse G; Padera, Timothy P.
Afiliación
  • Pereira ER; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Kedrin D; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Seano G; Division of Gastroenterology, MGH and HMS, Boston, MA 02114, USA.
  • Gautier O; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Meijer EFJ; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Jones D; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Chin SM; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Kitahara S; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Bouta EM; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Chang J; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Beech E; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Jeong HS; Graduate Program in Immunology, Division of Medical Sciences, HMS, Boston, MA 02115, USA.
  • Carroll MC; Program in Cellular and Molecular Medicine, Children's Hospital Boston and HMS, Boston, MA 02115, USA.
  • Taghian AG; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
  • Padera TP; Department of Otorhinolaryngology and Head and Neck Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Science ; 359(6382): 1403-1407, 2018 03 23.
Article en En | MEDLINE | ID: mdl-29567713
ABSTRACT
Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and trace their fate. We found that a fraction of these cells invaded lymph node blood vessels, entered the blood circulation, and colonized the lung. Thus, in mouse models, lymph node metastases can be a source of cancer cells for distant metastases. Whether this mode of dissemination occurs in cancer patients remains to be determined.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Ganglios Linfáticos / Metástasis Linfática / Siembra Neoplásica Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Ganglios Linfáticos / Metástasis Linfática / Siembra Neoplásica Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos