Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing.

Eng, Diana G; Kaverina, Natalya V; Schneider, Remington R S; Freedman, Benjamin S; Gross, Kenneth W; Miner, Jeffrey H; Pippin, Jeffrey W; Shankland, Stuart J

Eng, Diana G; Kaverina, Natalya V; Schneider, Remington R S; Freedman, Benjamin S; Gross, Kenneth W; Miner, Jeffrey H; Pippin, Jeffrey W; Shankland, Stuart J.

Afiliación

Eng DG; Division of Nephrology, University of Washington, Seattle, Washington, USA.
Kaverina NV; Division of Nephrology, University of Washington, Seattle, Washington, USA.
Schneider RRS; Division of Nephrology, University of Washington, Seattle, Washington, USA.
Freedman BS; Division of Nephrology, University of Washington, Seattle, Washington, USA.
Gross KW; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Miner JH; Division of Nephrology, Washington University School of Medicine, St. Louis, Missouri, USA.
Pippin JW; Division of Nephrology, University of Washington, Seattle, Washington, USA.
Shankland SJ; Division of Nephrology, University of Washington, Seattle, Washington, USA. Electronic address: stuartjs@uw.edu.

Kidney Int ; 93(5): 1240-1246, 2018 05.

Article en En | MEDLINE | ID: mdl-29580637

Asunto(s)

Linaje de la Célula; Rastreo Celular/métodos; Transdiferenciación Celular; Glomeruloesclerosis Focal y Segmentaria/metabolismo; Podocitos/metabolismo; Renina/metabolismo; Células Madre/metabolismo; Animales; Biomarcadores; Modelos Animales de Enfermedad; Femenino; Genes Reporteros; Glomeruloesclerosis Focal y Segmentaria/patología; Proteínas Luminiscentes/biosíntesis; Proteínas Luminiscentes/genética; Masculino; Ratones Transgénicos; Microscopía Fluorescente; Fenotipo; Podocitos/patología; Renina/genética; Células Madre/patología

Palabras clave

Cre-recombination; FLP-recombination reporter mouse; enalapril; glomerulus; lineage tracing; migration; podocin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre / Glomeruloesclerosis Focal y Segmentaria / Renina / Linaje de la Célula / Podocitos / Transdiferenciación Celular / Rastreo Celular Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Kidney Int Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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