Does neutrophil to lymphocyte ratio demonstrate deterioration in renal function?
Ren Fail
; 40(1): 209-212, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-29616601
ABSTRACT
INTRODUCTION:
Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy.METHODS:
We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient. Patients were divided into four groups Group 1 (n = 46) Healthy controls; Group 2 (n = 50) Patients who had undergone unilateral partial nephrectomy; Group 3 (n = 46) Patients who had gone unilateral nephrectomy; Group 4 (n = 82) Patients who had CKD.RESULTS:
The mean NLR of each group was as follows Group 1 2.14 ± 0.73; Group 2 3.52 ± 3.74; Group 3 3.64 ± 3.52, and Group 4 3.53 ± 2.30. NLR was lower in Group 1 compared to other groups but statistically significant difference was observed only between Group 1 (control) and Group 4 (CKD), 2.14 ± 0.73 versus 3.53 ± 2.30 (p = .005). In non-parametric correlation analysis NLR was found negatively correlated with GFR and positively correlated CKD stage (p = .028 for both correlations).CONCLUSIONS:
The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Insuficiencia Renal Crónica
/
Riñón
/
Nefrectomía
/
Neutrófilos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ren Fail
Asunto de la revista:
NEFROLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Turquía