Inflammatory biomarkers to guide diagnostic and therapeutic decisions in children presenting with fever without apparent source.
J Chemother
; 30(5): 255-265, 2018 Sep.
Article
en En
| MEDLINE
| ID: mdl-29619901
ABSTRACT
A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the diagnostic performance of inflammatory biomarkers in children with fever without apparent source and their usefulness in clinical decision-making. Data source was the Pubmed database. Thirteen studies were included, analysing the following biomarkers erythrocyte sedimentation rate, white blood count, absolute neutrophil count, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and the Lab-score (a combination of CRP, PCT and urine dipstick). Among the available biomarkers, CRP and PCT seem to be the most useful, showing the best performance at a threshold of 20 mg/L for CRP and 0.5 ng/mL for PCT. Lab-score increases diagnostic accuracy and also health-care costs. PCT demonstrated higher specificity levels, particularly in younger children. However, CRP remains the most accessible biomarker and is also available as a validated point-of-care test.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Fiebre
/
Inflamación
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Child
/
Humans
Idioma:
En
Revista:
J Chemother
Asunto de la revista:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia