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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Liu, Yang; Sethi, Nilay S; Hinoue, Toshinori; Schneider, Barbara G; Cherniack, Andrew D; Sanchez-Vega, Francisco; Seoane, Jose A; Farshidfar, Farshad; Bowlby, Reanne; Islam, Mirazul; Kim, Jaegil; Chatila, Walid; Akbani, Rehan; Kanchi, Rupa S; Rabkin, Charles S; Willis, Joseph E; Wang, Kenneth K; McCall, Shannon J; Mishra, Lopa; Ojesina, Akinyemi I; Bullman, Susan; Pedamallu, Chandra Sekhar; Lazar, Alexander J; Sakai, Ryo; Thorsson, Vésteinn; Bass, Adam J; Laird, Peter W.
Afiliación
  • Liu Y; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Sethi NS; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Hinoue T; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Schneider BG; Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Cherniack AD; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Sanchez-Vega F; Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Seoane JA; Department of Medicine, and Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Farshidfar F; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgarry, Canada.
  • Bowlby R; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Islam M; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Kim J; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  • Chatila W; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Akbani R; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kanchi RS; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Rabkin CS; Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Willis JE; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Wang KK; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
  • McCall SJ; Department of Pathology, Duke University, Durham, NC 27710, USA.
  • Mishra L; Center for Translational Research, Department of Surgery, George Washington University Cancer Center, Washington, DC 20052, USA.
  • Ojesina AI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
  • Bullman S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Pedamallu CS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Sakai R; PharmiWeb Solutions, Bracknell RG12 1QB, UK.
  • Thorsson V; Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address: vesteinn.thorsson@systemsbiology.org.
  • Bass AJ; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, US
  • Laird PW; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: peter.laird@vai.org.
Cancer Cell ; 33(4): 721-735.e8, 2018 04 09.
Article en En | MEDLINE | ID: mdl-29622466
ABSTRACT
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Metilación de ADN / Inestabilidad Cromosómica / ADN Polimerasa II / Homólogo 1 de la Proteína MutL / Proteínas de Unión a Poli-ADP-Ribosa / Neoplasias Gastrointestinales Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Metilación de ADN / Inestabilidad Cromosómica / ADN Polimerasa II / Homólogo 1 de la Proteína MutL / Proteínas de Unión a Poli-ADP-Ribosa / Neoplasias Gastrointestinales Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos