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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.
Wu, Cheng-Yang; Tso, Shih-Chia; Chuang, Jacinta L; Gui, Wen-Jun; Lou, Mingliang; Sharma, Gaurav; Khemtong, Chalermchai; Qi, Xiangbing; Wynn, R Max; Chuang, David T.
Afiliación
  • Wu CY; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Tso SC; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chuang JL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Gui WJ; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Lou M; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
  • Sharma G; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Khemtong C; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Qi X; Chemistry Center, National Institute of Biological Science, Beijing, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
  • Wynn RM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: richard.wynn@utsouthwestern.edu.
  • Chuang DT; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: david.chuang@utsouthwestern.edu.
Mol Metab ; 12: 12-24, 2018 06.
Article en En | MEDLINE | ID: mdl-29656110
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Piruvato Deshidrogenasa / Factores de Transcripción / Proteínas Nucleares / Transducción de Señal / Lipogénesis / Insulina / Obesidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Mol Metab Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Piruvato Deshidrogenasa / Factores de Transcripción / Proteínas Nucleares / Transducción de Señal / Lipogénesis / Insulina / Obesidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Mol Metab Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos