Human <i>N</i>-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.

Kadirvelraj, Renuka; Yang, Jeong-Yeh; Sanders, Justin H; Liu, Lin; Ramiah, Annapoorani; Prabhakar, Pradeep Kumar; Boons, Geert-Jan; Wood, Zachary A; Moremen, Kelley W

Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.

Kadirvelraj, Renuka; Yang, Jeong-Yeh; Sanders, Justin H; Liu, Lin; Ramiah, Annapoorani; Prabhakar, Pradeep Kumar; Boons, Geert-Jan; Wood, Zachary A; Moremen, Kelley W.

Afiliación

Kadirvelraj R; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602.
Yang JY; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712.
Sanders JH; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602.
Liu L; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712.
Ramiah A; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712.
Prabhakar PK; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712.
Boons GJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712.
Wood ZA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602; zaw@uga.edu moremen@uga.edu.
Moremen KW; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602; zaw@uga.edu moremen@uga.edu.

Proc Natl Acad Sci U S A ; 115(18): 4637-4642, 2018 05 01.

Article en En | MEDLINE | ID: mdl-29666272

Asunto(s)

N-Acetilglucosaminiltransferasas/química; Pliegue de Proteína; Uridina Difosfato N-Acetilglucosamina/química; Humanos; N-Acetilglucosaminiltransferasas/metabolismo; Dominios Proteicos; Uridina Difosfato N-Acetilglucosamina/metabolismo

Palabras clave

N-glycan processing; convergent evolution; exosite; glycosyltranferase; substrate recognition

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Uridina Difosfato N-Acetilglucosamina / Pliegue de Proteína / N-Acetilglucosaminiltransferasas Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

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