Ex vivo mouse brain microscopy at 15T with loop-gap RF coil.
Magn Reson Imaging
; 51: 1-6, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29679634
ABSTRACT
The design of a loop-gap-resonator RF coil optimized for ex vivo mouse brain microscopy at ultra high fields is described and its properties characterized using simulations, phantoms and experimental scans of mouse brains fixed in 10% formalin containing 4â¯mM Magnevist™. The RF (B1) and magnetic field (B0) homogeneities are experimentally quantified and compared to electromagnetic simulations of the coil. The coil's performance is also compared to a similarly sized surface coil and found to yield double the sensitivity. A three-dimensional gradient-echo (GRE) sequence is used to acquire high resolution mouse brain scans at (47⯵m)3 resolution in 1.8â¯h and a 20â¯×â¯20â¯×â¯19⯵m3 resolution in 27â¯h. The high resolution obtained permitted clear visualization and identification of multiple structures in the ex vivo mouse brain and represents, to our knowledge, the highest resolution ever achieved for a whole mouse brain. Importantly, the coil design is simple and easy to construct.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Imagen por Resonancia Magnética
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Microscopía
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2018
Tipo del documento:
Article