Minimum Action Path Theory Reveals the Details of Stochastic Transitions Out of Oscillatory States.
Phys Rev Lett
; 120(12): 128102, 2018 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-29694079
ABSTRACT
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Transitions between such states are studied as noise-driven escape problems in the chemical species space. Escape can occur via multiple possible multidimensional paths, with probabilities depending nonlocally on the noise. Here we characterize the escape from an oscillatory biochemical state by minimizing the Freidlin-Wentzell action, deriving from it the stochastic spiral exit path from the limit cycle. We also use the minimized action to infer the escape time probability density function.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Relojes Biológicos
/
Modelos Biológicos
Idioma:
En
Revista:
Phys Rev Lett
Año:
2018
Tipo del documento:
Article
País de afiliación:
España