Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.

Bratt, Jennifer M; Chang, Kevin Y; Rabowsky, Michelle; Franzi, Lisa M; Ott, Sean P; Filosto, Simone; Goldkorn, Tzipora; Arif, Muhammad; Last, Jerold A; Kenyon, Nicholas J; Zeki, Amir A

Bratt, Jennifer M; Chang, Kevin Y; Rabowsky, Michelle; Franzi, Lisa M; Ott, Sean P; Filosto, Simone; Goldkorn, Tzipora; Arif, Muhammad; Last, Jerold A; Kenyon, Nicholas J; Zeki, Amir A.

Afiliación

Bratt JM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Chang KY; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Rabowsky M; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Franzi LM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Ott SP; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Filosto S; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Goldkorn T; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Arif M; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Last JA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Kenyon NJ; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Zeki AA; Department of Internal Medicine, Respiratory Signal Transduction, Genome and Biomedical Sciences Facility, University of California, Davis, Davis, CA 95616.

J Immunol ; 200(11): 3840-3856, 2018 06 01.

Article en En | MEDLINE | ID: mdl-29703864

Asunto(s)

Asma/tratamiento farmacológico; Hiperreactividad Bronquial/tratamiento farmacológico; Eosinófilos/efectos de los fármacos; Farnesiltransferasa/antagonistas & inhibidores; Inflamación/tratamiento farmacológico; Fosfatos de Poliisoprenilo/metabolismo; Sesquiterpenos/metabolismo; Proteínas ras/metabolismo; Animales; Asma/metabolismo; Bronquios/efectos de los fármacos; Bronquios/metabolismo; Hiperreactividad Bronquial/metabolismo; Modelos Animales de Enfermedad; Inhibidores Enzimáticos/farmacología; Eosinófilos/metabolismo; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Farnesiltransferasa/metabolismo; Humanos; Inflamación/metabolismo; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Masculino; Metionina/análogos & derivados; Metionina/farmacología; Ratones; Ratones Endogámicos BALB C; Ovalbúmina/farmacología; Transducción de Señal/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatos de Poliisoprenilo / Asma / Sesquiterpenos / Hiperreactividad Bronquial / Proteínas ras / Eosinófilos / Farnesiltransferasa / Inflamación Límite: Animals / Humans / Male Idioma: En Revista: J Immunol Año: 2018 Tipo del documento: Article

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