Reciprocal loop of hypoxia-inducible factor-1&#945; (HIF-1&#945;) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.

Zhu, Shuai; Deng, Shijiang; He, Chi; Liu, Mingliang; Chen, Hengyu; Zeng, Zhu; Zhong, Jianxin; Ye, Zeng; Deng, Shichang; Wu, Heshui; Wang, Chunyou; Zhao, Gang

Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.

Zhu, Shuai; Deng, Shijiang; He, Chi; Liu, Mingliang; Chen, Hengyu; Zeng, Zhu; Zhong, Jianxin; Ye, Zeng; Deng, Shichang; Wu, Heshui; Wang, Chunyou; Zhao, Gang.

Afiliación

Zhu S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Deng S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
He C; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Liu M; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Chen H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zeng Z; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zhong J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Ye Z; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Deng S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Wu H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Wang C; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zhao G; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.

J Pathol ; 245(3): 349-360, 2018 07.

Article en En | MEDLINE | ID: mdl-29708271

Asunto(s)

Adenocarcinoma/metabolismo; Antígenos CD/metabolismo; Cadherinas/metabolismo; Histona Desacetilasas/metabolismo; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Neoplasias Pancreáticas/metabolismo; Proteínas Represoras/metabolismo; Acetilación; Adenocarcinoma/genética; Adenocarcinoma/secundario; Animales; Antígenos CD/genética; Cadherinas/genética; Línea Celular Tumoral; Movimiento Celular; Proliferación Celular; Regulación hacia Abajo; Transición Epitelial-Mesenquimal; Femenino; Regulación Neoplásica de la Expresión Génica; Histona Desacetilasa 1/metabolismo; Histona Desacetilasas/genética; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Ratones Endogámicos BALB C; Invasividad Neoplásica; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patología; Procesamiento Proteico-Postraduccional; Estabilidad Proteica; Proteínas Represoras/genética; Elementos de Respuesta; Transducción de Señal; Transcripción Genética; Carga Tumoral

Palabras clave

E-cadherin; HIF-1α; MTA2; hypoxia; pancreatic carcinoma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Represoras / Adenocarcinoma / Antígenos CD / Cadherinas / Subunidad alfa del Factor 1 Inducible por Hipoxia / Histona Desacetilasas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: J Pathol Año: 2018 Tipo del documento: Article

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