Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease.
Clin Sci (Lond)
; 132(8): 901-904, 2018 04 30.
Article
en En
| MEDLINE
| ID: mdl-29712884
ABSTRACT
The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease. However, links amongst gut pathology, microbial ecology, and blood pressure remain elusive. In a recent issue of Clinical Science (vol. 132, issue 6, 701-718), Kim et al. demonstrate a crucial link between gut microbiota and bacterial metabolites such as butyrate, gut leakiness, and hypertension.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Microbioma Gastrointestinal
/
Hipertensión
Límite:
Humans
Idioma:
En
Revista:
Clin Sci (Lond)
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá