Hypotension and cutaneous reactions associated with intravenous administration of etoposide in the dog.
Am J Vet Res
; 49(8): 1367-70, 1988 Aug.
Article
en En
| MEDLINE
| ID: mdl-2972235
ABSTRACT
A study was undertaken to determine the pressor and toxic effects of etoposide, an antineoplastic agent, when administered IV in 0.9% sodium chloride solution (0.4 mg of etoposide/ml) over a 30-minute period to dogs at a dosage of 40 mg/m2 of body surface. On day 1, 6 adult German Shorthaired Pointers were anesthetized with halothane, and blood pressures were measured via a femoral artery catheter before, during, and after the etoposide was administered. Systolic, diastolic, and mean blood pressures of each dog decreased [corrected] significantly (P less than 0.01) within 30 minutes after initiation of etoposide infusion. On day 3, when the dogs were not anesthetized, etoposide was again administered to each dog, using the same dosage. Each dog developed a moderate to severe cutaneous reaction characterized by moderate to severe pruritus, urticaria, and swelling of the head and extremities that began during the second infusion of etoposide. These same cutaneous reactions were seen on day 30, when etoposide was administered to 3 of the previously treated dogs and 2 previously untreated Beagles. We concluded that the administration of the commercial preparation of etoposide is likely to cause a significant reduction in blood pressure of anesthetized dogs, and that the drug is likely to induce a moderate to severe cutaneous reaction when administered to unanesthetized dogs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Erupciones por Medicamentos
/
Enfermedades de los Perros
/
Etopósido
/
Hipotensión
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Am J Vet Res
Año:
1988
Tipo del documento:
Article