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Autophagy in inflammation: the p38α MAPK-ULK1 axis.
She, Hua; He, Yingli; Zhao, Yingren; Mao, Zixu.
Afiliación
  • She H; Department of Pharmacology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 USA.
  • He Y; Department of Neurology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 USA.
  • Zhao Y; Department of Infectious Diseases, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710000 China.
  • Mao Z; Department of Infectious Diseases, The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710000 China.
Macrophage (Houst) ; 52018.
Article en En | MEDLINE | ID: mdl-29732413
ABSTRACT
Autophagy and inflammation are two processes vital for immune cells to perform their functions. Their proper interplay upon signal is pivotal for proper response to stress. The stress kinase p38α MAPK in microglia senses inflammatory cue LPS, directly phosphorylates ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Macrophage (Houst) Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Macrophage (Houst) Año: 2018 Tipo del documento: Article