ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.

Shen, Jianfeng; Ju, Zhenlin; Zhao, Wei; Wang, Lulu; Peng, Yang; Ge, Zhongqi; Nagel, Zachary D; Zou, Jun; Wang, Chen; Kapoor, Prabodh; Ma, Xiangyi; Ma, Ding; Liang, Jiyong; Song, Shumei; Liu, Jinsong; Samson, Leona D; Ajani, Jaffer A; Li, Guo-Min; Liang, Han; Shen, Xuetong; Mills, Gordon B; Peng, Guang

Shen, Jianfeng; Ju, Zhenlin; Zhao, Wei; Wang, Lulu; Peng, Yang; Ge, Zhongqi; Nagel, Zachary D; Zou, Jun; Wang, Chen; Kapoor, Prabodh; Ma, Xiangyi; Ma, Ding; Liang, Jiyong; Song, Shumei; Liu, Jinsong; Samson, Leona D; Ajani, Jaffer A; Li, Guo-Min; Liang, Han; Shen, Xuetong; Mills, Gordon B; Peng, Guang.

Afiliación

Shen J; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ju Z; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhao W; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang L; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Peng Y; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ge Z; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nagel ZD; Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zou J; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang C; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kapoor P; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA.
Ma X; Cancer Biology Research Center; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ma D; Cancer Biology Research Center; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liang J; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Song S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Liu J; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Samson LD; Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ajani JA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Liang H; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shen X; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA.
Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Peng G; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. gpeng@mdanderson.org.

Nat Med ; 24(5): 556-562, 2018 05.

Article en En | MEDLINE | ID: mdl-29736026

Asunto(s)

Inmunoterapia; Mutación/genética; Neoplasias/genética; Neoplasias/inmunología; Proteínas Nucleares/deficiencia; Proteínas Nucleares/genética; Factores de Transcripción/deficiencia; Factores de Transcripción/genética; Animales; Línea Celular Tumoral; Reparación de la Incompatibilidad de ADN; Proteínas de Unión al ADN; Femenino; Humanos; Linfocitos Infiltrantes de Tumor/inmunología; Ratones Endogámicos C57BL; Proteína 2 Homóloga a MutS/metabolismo; Unión Proteica

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Inmunoterapia / Mutación / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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