The FOAM study: is Hysterosalpingo foam sonography (HyFoSy) a cost-effective alternative for hysterosalpingography (HSG) in assessing tubal patency in subfertile women? Study protocol for a randomized controlled trial.
BMC Womens Health
; 18(1): 64, 2018 05 09.
Article
en En
| MEDLINE
| ID: mdl-29743106
ABSTRACT
BACKGROUND:
Tubal pathology is a causative factor in 20% of subfertile couples. Traditionally, tubal testing during fertility work-up is performed by hysterosalpingography (HSG). Hysterosalpingo-foam sonography (HyFoSy) is a new technique that is thought to have comparable accuracy as HSG, while it is less expensive and more patient friendly. HyFoSy would be an acceptable alternative for HSG, provided it has similar effectiveness in terms of patient outcomes. METHODS/DESIGN:
We aim to compare the effectiveness and costs of management guided by HyFoSy or by HSG. Consenting women will undergo tubal testing by both HyFoSy and HSG in a randomized order during fertility work-up. The study group will consist of 1163 subfertile women between 18 and 41 years old who are scheduled for tubal patency testing during their fertility work-up. Women with anovulatory cycles not responding to ovulation induction, endometriosis, severe male subfertility or a known contrast (iodine) allergy will be excluded. We anticipate that 7 % (N = 82) of the participants will have discordant test results for HyFoSy and HSG. These participants will be randomly allocated to either a management strategy based on HyFoSy or a management strategy based on HSG, resulting in either a diagnostic laparoscopy with chromopertubation or a strategy that assumes tubal patency (intrauterine insemination or expectant management). The primary outcome is ongoing pregnancy leading to live birth within 12 months after randomization. Secondary outcomes are patient pain scores, time to pregnancy, clinical pregnancy, miscarriage rate, multiple pregnancy rate, preterm birth rate and number of additional treatments. Costs will be estimated by counting resource use and calculating unit prices.DISCUSSION:
This trial will compare the effectiveness and costs of HyFoSy versus HSG in assessing tubal patency in subfertile women. TRIAL REGISTRATION Dutch Trial Register (NTR 4746, http//www.trialregister.nl ). Date of registration 19 August 2014.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Histerosalpingografía
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Ensayos Clínicos Controlados Aleatorios como Asunto
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Estudios Multicéntricos como Asunto
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Ultrasonografía
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Enfermedades de las Trompas Uterinas
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Trompas Uterinas
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Infertilidad Femenina
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Health_economic_evaluation
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Qualitative_research
Límite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
BMC Womens Health
Asunto de la revista:
SAUDE DA MULHER
Año:
2018
Tipo del documento:
Article
País de afiliación:
Países Bajos