Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin.
Clin Case Rep
; 6(5): 788-791, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-29744057
ABSTRACT
One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell-free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false-positive outcome for a normal, viable twin. We show that a vanishing trisomy-14 twin contributes to cfDNA for more than 2 weeks after demise.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Clin Case Rep
Año:
2018
Tipo del documento:
Article