Intraoperative radiation therapy for rectal cancer and recurrent intra-abdominal sarcomas.
Acta Chir Belg
; 119(2): 95-102, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-29745309
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the effect of high-dose-rate intraoperative radiation therapy (HDR-IORT) in a multimodality treatment on the local control (LC) and the overall survival (OS) rate in locally advanced rectal cancer (LARC), locally recurrent rectal cancer (LRRC) and recurrent intra-abdominal sarcomas (RS). MATERIALS ANDMETHODS:
A retrospective analysis was performed on 27 patients who were treated with radical resection and HDR-IORT between April 2007 and January 2017. Patient, tumor and surgical characteristics were analyzed and the perioperative (<30 days) and long-term complications (>30 days) were assessed and graded.RESULTS:
None of the patients with LARC (n = 4) developed a local recurrence and all patients were still alive at the end of the follow-up. The LC rates of LRRC (n = 17) after one and three years were respectively 48% and 40% and the one, three and five years OS were respectively 93%, 62% and 44%. For RS (n = 6), the LC rates after one and three years were both 33% and the one and three years OS rate were respectively 83% and 46%.CONCLUSIONS:
The results of our study show that HDR-IORT could be a valuable asset in the multimodality management of LARC, LRRC and RS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
/
Neoplasias Retroperitoneales
/
Sarcoma
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Chir Belg
Año:
2019
Tipo del documento:
Article
País de afiliación:
Bélgica